The premier will leave on Monday night and visit Beijing and Jiangsu and Sichuan provinces before returning to Melbourne on Saturday morning.

The trip comes two years after the former Morrison government tore up Victoria's agreement with Beijing, which was classified as part of China's contentious global Belt and Road infrastructure strategy.

Mr Andrews said on Sunday China was Victoria's largest and most significant trading partner and it was important to strengthen that relationship even further.

"It's not a trip that's designed to sign deals. It's not a trip that's designed to be touring and making announcements about investments," he told reporters.

"It's about sending the clearest message that we value this partnership. It's always been important to us and arguably it's more important than ever.

"This is not the first trip that I've made to China and it won't be the last."

Mr Andrews said Prime Minister Anthony Albanese was supportive of the six-day mission.

The Victorian premier denied the relationship between Canberra and Beijing was strained after the $368 billion AUKUS submarine deal.

"I'm not here to be a commentator on the China-Australia relationship ... nor am I here to talk about defence or strategic issues or foreign policy issues," Mr Andrews said.

"My job, the job I have always done, is to make sure that more Victorian companies can get access to the biggest market in the world."

Deputy opposition leader David Southwick said Mr Andrews' China trip lacked transparency.

"There are a number of questions that certainly need to be asked, firstly, to understand what is the benefit of this trip to Victoria and to Victorians.

"What will Daniel Andrews be doing when he's over there and why has he been so secretive about this particular trip?" Mr Southwick told reporters.

Victoria strengthened ties with China in 2019 when it signed on to Beijing's Belt and Road initiative.

The agreement was designed to increase participation of Chinese companies in Victoria's infrastructure program and promoted co-operation of Victorian businesses in China.

But the Morrison government cancelled the agreement in March 2021, saying it was inconsistent with Australia's foreign policy or was adverse to foreign relations.

Sceptics have since raised concerns that China is laying a debt trap for some borrowing governments and at the same expanding its international power base via its so-called New Silk Road projects.

At the time, the Chinese embassy in Australia opposed the government's decision, calling it an unreasonable and provocative move.

Mr Andrews acknowledged that discussing infrastructure matters during his trip was not unlikely.

"I'm sure that infrastructure, both infrastructure needs in China and some of our challenges and needs here, may well be talked about," he said.

"This is the infrastructure capital of our nation so no doubt they'll be interested."

The media has not been invited to travel with him on the trip.

Australian Associated Press