A middle-aged man returning from Ballarat after getting his motorcycle licence was caught doing 130km/h during Operation Regal.
Hamilton police said two men on separate motorbikes were clocked together at 130km/h between Dunkeld and Hamilton over the long weekend blitz.
They have been fined $500 and banned from riding for three months.
One of the men had just completed getting his motorbike licence in Ballarat about 90 minutes before being pulled over.
South-west police road safety adviser Senior Sergeant Matt Wheeler said motorcycles significantly contributed to road trauma in the south-west and across Victoria.
He said that during the four-day police Queen's Birthday weekend operation resulted in 196 offences being detected across the south-west.
Eight drivers were caught under the influence of substances, six of alcohol and two of drugs, from 1481 tests.
The road safety adviser said that Warrnambool police had intercepted 20 drivers for speeding, making up more than 10 per cent of offences detected in the city.
He said speeding was a major contributor to road trauma.
"That statistics stand out to me. Over 10 per cent of offences involved speeding, that's really significant," Senior Sergeant Wheeler said.
"When you put all that together, the clear message needs to be for drivers to slow down.
"Drive up to the posted speed limit, if it is safe to do so, but motorists need to always consider road and weather conditions."
Senior Sergeant Wheeler said although there were a number of minor collisions in Warrnambool and district during the weekend, that there was only one serious injury accident and fortunately no fatalities.
He said that collisions involved a 65-year-old Mirranatwa man who crashed into a kangaroo about 3pm on Friday at Victoria Point, east of Cavendish.
A serious injury was recorded and the man was transported to hospital for assessment and treatment.
"When you are driving in an area known to be frequented by wildlife, motorists need to be aware, slow down and take precautions," Senior Sergeant Wheeler said.
Other offences included a a 57-year-old woman puled over in the Hamilton central business district on Monday morning at three times the legal alcohol limit.
She was also unlicensed and her car was impounded for one month, which will attract towing and storage fees of more than $1000.
The woman will be charged with drink driving and unlicensed driving and front the Hamilton Magistrates Court at a later date.
A 21-year-old P-plater was caught drink driving in Portland with a reading of .087 and another P-plater was intercepted between Hamilton and Dunkeld at 134km/h.
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