Operation Regal will run from midnight on Friday to midnight on Monday and is being held in conjunction with Operation Sentinel, which is currently limiting the movement of Melburnians into regional Victoria to prevent the spread of the recent coronavirus outbreak.

Under current restrictions, those living in metropolitan Melbourne are still banned from travelling into regional Victoria.

But police are still preparing for higher than usual numbers on the region's roads.

South-west police have reminded all motorists about the increased driving dangers associated with long weekend travel and have warned that the increase of high-risk driving behaviour such as speeding is even more likely.

Operation Regal will see police targeting the 'deadly five' - speed, alcohol and drug impaired driving, fatigue, driver distraction and a failure to wear seatbelts.

So far this year there have been 94 live lost on the state's roads with 50 per cent of fatalities occurring on roads in country or regional Victoria and one-third attributed to excessive or inappropriate speed.

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Police are urging motorists to slow down, consider other road users and be patient when driving in traffic, on unfamiliar roads and in potentially poor weather conditions.

Over the past five Queen's Birthday long weekends, there have been 17 lives lost on roads and a further 980 people injured.

A total of 48,811 traffic and criminal offences have been detected, including 25,719 for speeding.

With over 588,000 alcohol and drugs tests conducted over five previous Queen's Birthday operations, police have issued a stern warning to motorists considering drinking or taking drugs and driving this long weekend - you will get caught.

Operation Regal will involve personnel from all local road policing units, general duties, and other operational policing units, with targeted deployment of mobile speed cameras, Automated Number Plate Recognition vehicles and Victoria Police's fleet of Alcohol and Drug Testing vehicles.

Victoria Police assistant commissioner for road policing Libby Murphy said with two state-wide operations underway across the long weekend, motorists could expect to see a "bolstered police presence on the roads".

"With regional Victorians free to travel across the state, we're still anticipating a busy weekend on regional roads and major arterials," she said.

"Day trips are an increasingly popular pastime over the long weekend, however with this comes a higher risk of driver fatigue, distractions and speed.

"There have been 17 lives lost on Victorian roads over the previous five Queen's Birthday weekends. This weekend, please don't make an irresponsible decision behind the wheel that results in you or those around you becoming another unnecessary statistic that shatters families forever."

Assistant Commissioner Murphy said police would be conducting alcohol and drug testing at every opportunity.

"Our fleet of drug and alcohol testing vehicles will be out on the road, while every police car has the potential to perform a drug or alcohol test. If you drink or take drugs and drive, you will get caught," she said.

Poor weather conditions are expected across the long weekend, with damaging winds, heavy rain, snow and potential flooding.

"Avoid being on the road if you don't have to, slow down and leave extra space when driving in the wet and use your headlights to help see and be seen," the assistant commissioner said.

"Please slow down, be patient and drive cautiously in poor weather conditions and on unfamiliar roads"

"It's true, we can't be everywhere, but we will be somewhere - and if you act carelessly on our roads and put yourself and others at risk, you will be caught."

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