Victoria Police's Operation Nexus ran from Thursday until Monday and targeted speed, impaired driving, fatigue, seat belt compliance and mobile phone use.

Across the Warrnambool and Southern Grampians police service areas, there were 223 offence detected during the five-day operation, 183 of which were speeding.

Acting Senior Sergeant Cameron Ross, who overlooked the long weekend road operation in the south-west, said the highest speed was an interstate P-plater clocked at 149km/h on the Princes Highway with three young children in the car.

"The rest were mainly carrying speeds of between 10km/h and 25km/h (over the limit)," he said.

"Speeding was definitely our biggest driver across the road operation and it's concerning because any speed is dangerous.

"Studies show that 10km/h can make all the difference. It decreases your reaction time and if you're hitting something at a speed like that, it will cause injury, damage or death - that's a fact."

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Acting Senior Sergeant Ross said it was time to change driver behaviour.

"The messaging is clear but people are still complacent," he said.

"There's a lack of attention and they become used to speeding. It's not a good habit.

"There's a speed limit there for a reason."

Other offences detected included 10 unregistered vehicles, nine disobey signals, four without seat belts, three drink drivers, two cycling offences and one drug driver.

"Any figures relating to impaired driving is not good but it's pleasing to see that there wasn't a lot of people out and about driving drunk or on drugs," Acting Senior Sergeant Ross said.

"Being a long weekend and given the good weather, there would have been a lot of people visiting their family and friends, having a barbecue and celebrating, so it's good that those figures were down."

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One vehicle was impounded during the five-day period, which Acting Senior Sergeant Ross said was a disqualified driver.

He said usually offences like speeding or the use of mobile phones led police to discover motorists did not have a current driver's licence.

"We're always out there observing," Acting Senior Sergeant Ross said.

"And that goes beyond a long weekend road operation."

Victorian roads claimed the lives of five people in separate collisions, making it the worst Easter long weekend on the roads since 2007.

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