Motorists hitting the road for the long weekend are likely to see a much higher police presence starting first thing on Friday.
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Operation Regal will commence at 12.01am and will run to 11.59pm on Monday.
South-west police road safety manager Senior Sergeant Chris Asenjo said there was currently "unprecedented road trauma in our part of the world".
He said the south-west road toll stood at 10, compared with nine for all of 2018.
"We are well and truly over last year's tally and we're not even half way through the year," he said.
"It's a sobering statistic. At the end of the day there are local people dying on local roads.
"We've also had 59 people injured in serious collisions in this division. Those people's lives have been ruined forever.
"There is also those who aren't seriously injured. We've got trucks rolling over where fortunately people are not harmed.
"When you've got a car or a truck colliding with a tree or a pole, there is only a matter of inches between someone being injured and someone dying."
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Senior Sergeant Asenjo said the state-wide operation would focus on the five key causes of road trauma, being fatigue, seat belt compliance, impaired driving, speed and distraction.
"We will have additional resources deployed to road police tasking from major highways right through to the smaller roads," he said.
"We will have all available units on the roads, with support from our colleagues in Melbourne. We will have state highway patrol and heavy vehicle units as well as a unit solely targeting impaired driving.
"Motorists are urged to drive to the conditions, get to their destination safely and bloody pay attention.
"Our intel shows that the state of our roads has not caused a single fatality in this year's road toll. It's people doing what they shouldn't be."
The four-day road operation will also highlight the importance of slowing down to 40km/h when passing emergency services vehicles.
"It's about ensuring police and emergency services have a safe workplace," Senior Sergeant Asenjo said.
"Everyone is entitled to go to work and be safe. Some of our guys are on the road for a full eight hours. It's their office, their work space. This law was introduced to provide people with the safest possible work environment so it is absolutely necessary for motorists to adhere to that."
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