Police are negotiating with a suspected shooter at a property at Wedderburn, 75km north west of Bendigo.
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It is believed one person has been killed, with fears for two other people believed to be shot.
A police spokeswoman said police were negotiating with a man at a nearby residence, but it is unknown whether there is anyone else on the premises.
The spokeswoman said police were called to the property around 8:30pm on Wednesday but could not confirm at this stage whether anyone had been injured.
Locals told Fairfax Media that the incident occurred on a farm just outside the township. A police roadblock has been set up at the intersection of Calder Highway and Wedderburn-Logan Road.
Serveral ambulances are in attendance as well as the SES.