Leading Senior Constable Lee Thomson said police believed that a driver lost control of his blue Holden when heading north-west on Sunbury Road. The car collided with two other cars near the suburb of Melbourne Airport about 5.15pm.

The driver was taken to the Royal Melbourne Hospital in a "serious but not life-threatening condition", a Victoria Police spokeswoman said.

The two men in the second car died at the scene, while the male driver of the third car was unharmed.

Senior Constable Thomson said police were investigating the collision and urged anyone with information to call Crime Stoppers on 1800 333 000 or visit www.crimestoppersvic.com.au