Victoria Police made the decision to open the road, west of Derrinallum, from 4pm today.

It follows a three-week operation to clear a property that was the site of a series of massive blasts in the early hours of April 12.

Owner Glenn Sanders triggered the explosions, injuring two policemen and killing himself.

Explosives experts from the police bomb squad, Australian Federal Police and the Army were called in to clear the property in what became the largest operation of its kind in Australia.

A one-kilometre exclusion zone was set up around the property and police manned 24-hour road blocks. 

Acting Superintendent Paul Ross said the road was now open to traffic but speed restrictions are in place at the front of the property.

"We've done an assessment and determined that traffic can use the road safely," he said.

He said police would continue to work to gather evidence and clear the property. 

"Access to the site is still restricted."